A03

© UDE/Bettina Engel-Albustin

Project Area A - Biology and Molecular Oncology

Prof. Dr. Hemmo Meyer

Molecular Biology I

University of Duisburg-Essen

Phone: +49 201 183 4217
Email

VCP/p97-cofactor complexes at the intersection of DNA repair and checkpoint control

Meyer will concentrate on deconvolving the functions of the VCP/p97 ATPase and its many cofactor proteins in DNA damage responses. He will use a systematic combination of mass spectrometry, PROTAC-induced protein degradation and cell-free reconstitution approaches. The aim is to identify targets and dissect the exact role of p97-cofactor complexes in alternative DNA damage repair pathways and checkpoint signaling that control cell state transitions, and then explore the relevance for genomic stability and survival in cancer cell models.

Project Members

Dr. Maike Reinders

[email protected]

Daniella Munro

[email protected]

Alexander Kröning

[email protected]

Sandra Koska

[email protected]

Publications

    Journal articles

  • Huang, Jing; Jaekel, Andreas; van den Boom, Johannes; Podlesainski, David; Elnaggar, M.; Heuer-Jungemann, A.; Kaiser, Markus; Meyer, Hemmo; Saccà, Barbara
    A modular DNA origami nanocompartment for engineering a cell-free, protein unfolding and degradation pathway
    In: Nature Nanotechnology , Vol. 19 2024 , Nr. 10 , pp. 1521 - 1531
    DOI (Open Access)
  • Kück, Anja; van den Boom, Johannes; Koska, Sandra; Ron, David; Meyer, Hemmo
    Alternating binding and p97-mediated dissociation of SDS22 and I3 recycles active PP1 between holophosphatases
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Vol. 121 2024 , Nr. 36 , e2408787121
    DOI (Open Access)
  • Gahlot, Pinki; Kravic, Bojana; Rota, Giulia; van den Boom, Johannes; Levantovsky, Sophie; Schulze, Nina; Maspero, Elena; Polo, Simona; Behrends, Christian; Meyer, Hemmo
    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
    In: Molecular Cell 2024 , pp. 1556 - 1569.e10
    DOI, Online Full Text (Open Access)
  • Meyer, Hemmo; Kravic, Bojana
    The Endo-Lysosomal Damage Response
    In: Annual Review of Biochemistry , Vol. 93 2024 , Nr. 1 , pp. 367 - 387
    DOI (Open Access)
  • Mirsanaye, Ann Schirin; Hoffmann, Saskia; Weisser, Melanie; Mund, Andreas; Lopez Mendez, Blanca; Typas, Dimitris; van den Boom, Johannes; Benedict, Bente; Hendriks, Ivo A.; Nielsen, Michael Lund; Meyer, Hemmo; Duxin, Julien P.; Montoya, Guillermo; Mailand, Niels
    VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates
    In: Nature Communications , Vol. 15 2024 , Nr. 1 , 2459
    DOI (Open Access)
  • van den Boom, Johannes; Marini, Guendalina; Meyer, Hemmo; Saibil, Helen R
    Structural basis of ubiquitin-independent PP1 complex disassembly by p97
    In: The EMBO Journal , Vol. 42 2023 , Nr. 14 , e113110
    DOI (Open Access)
  • Meyer, Hemmo; van den Boom, Johannes
    Targeting of client proteins to the VCP/p97/Cdc48 unfolding machine
    In: Frontiers in Molecular Biosciences , Vol. 10 2023 , 1142989
    DOI, Online Full Text (Open Access)
  • Blüggel, Mike; Kröning, Alexander; Kracht, Matthias; van den Boom, Johannes; Dabisch, Matthias; Göhring, Anna; Kaschani, Farnusch; Kaiser, Markus; Bayer, Peter; Meyer, Hemmo; Beuck, Christine
    The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPase
    In: Nature Communications , Vol. 14 2023 , Nr. 1 , 3258
    DOI, Online Full Text (Open Access)
  • Kravić, Bojana; Bionda, Tihana; Siebert, Alexander; Gahlot, Pinki; Levantovsky, Sophie; Behrends, Christian; Meyer, Hemmo
    Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1
    In: Molecular Cell , Vol. 82 2022 , Nr. 14 , pp. 2633 - 2649.e7
    DOI (Open Access)
  • Kröning, Alexander; van den Boom, Johannes; Kracht, Matthias; Kück, Anja; Meyer, Hemmo
    Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTN
    In: The Journal of Biological Chemistry (JBC) , Vol. 298 2022 , Nr. 6 , 101976
    DOI (Open Access)

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